White M. Schenkels MJ. Engbers FH. Vletter A. Burm AG. Bovill JG. Kenny GN.
Institution
Department of Anaesthesiology, Leiden University Medical Centre, The
Netherlands.
Title
Effect-site modelling of propofol using auditory evoked potentials.
Source
British Journal of Anaesthesia. 82(3):333-9, 1999 Mar.
Abstract
Auditory evoked potentials (AEP) were used to monitor central nervous
system effects during induction and recovery from anaesthesia produced by
infusion of propofol 30 mg kg-1 h-1 in 22 healthy male patients.
Non-parametric and parametric modelling techniques were used successfully to
calculate the parameter keo which linked pharmacokinetic with
pharmacodynamic aspects of drug action in only 15 of the study patients. In
the non-parametric analysis, keo was found to have a mean value of 0.2
(range 0.1-0.36) min-1. Estimation of keo allowed calculation of the
effect-site concentration (Ce50) associated with 50% of AEP effect for the
population (2.08 micrograms ml-1; 95% confidence limits 1.7-2.45). There
were no significant differences between keo values calculated by
non-parametric and individual parametric modelling techniques. During
recovery, 50% of patients demonstrated evidence of waking at an effect-site
concentration of 2.28 micrograms ml-1.